Infectious diseases posed a persistent threat in the United States between 2014 and 2017. Several cases were reported between 2016 and 2017, despite high vaccination rates. Infectious diseases created even worse threats for residents in proximity to each other, such as college campuses. This study analyzes and models the dynamics of infectious diseases within a college setting, employing the notorious Harvard mumps outbreak of 2016 as a case study. It draws data from the Harvard University outbreak to offer a valuable framework for managing infectious disease outbreaks in educational environments. This paper provides insights into how college-level socialization, dormitories, classrooms, and social networks affect transmission rates, disease spread, quarantining, and vaccination campaigns. These factors are unique to educational institutions as they contribute a new perspective to public health strategies for colleges on infectious diseases and develop proactive intervention planning.