The Water-Energy-Food Nexus planning is grounded on the three pillars of sustainability: economy, society, and environment. Addressing the needs of the steadily growing global population has emerged as an increasingly urgent challenge. The inherent conflicts among objectives within economic, social, and environmental dimensions and the shortage of required resources are exacerbating the pressure. Land degradation, together with climate change and other disruptive phenomena, is making difficult to meet the growing demand for food. Thus, conscious decision-making processes on all the three decision-making levels, i.e., strategic, tactical, and operational, require quantitative analyses which take into account the current situation. As a novel contribution, in this work two Single-Objective Mixed-Integer Linear Programming models based on a Water-Energy-Food-Land Nexus system are proposed. Then, a what-if analysis based on hypothetical real-world scenarios, considering reductions in crop yields and changes in fossil fuel availability, is carried out.