Dupuytren’s disease is a progressive fibromatosis of the hand that can result in significant functional impairment. Many traditional treatments including partial fasciectomy, percutaneous needle aponeurotomy (PNA), and collagenase injections are commonly used; however, they often show high recurrence rates and potential complications. Corticosteroid injections, while being documented in the literature for decades, remain underutilized in clinical practice. This chapter provides a complete review of the pathophysiology of Dupuytren’s disease, the antifibrotic mechanisms of corticosteroids, and their clinical application. Triamcinolone acetonide, in particular, has shown efficacy in softening and reducing nodules through its effects on collagen metabolism and fibroblast activity. We address effective dosing regimens, injection procedures, and safety concerns, as well as evidence supporting corticosteroid injections in early nodules and as an adjuvant therapy after surgery. By combining current evidence, this chapter provides insights on corticosteroid use as a feasible and underutilized treatment for Dupuytren’s disease.