Sickle cell disease is a rare inherited, lifelong blood disorder affecting an estimated 100,000 individuals in the United States (Centers for Disease Control and Prevention. Sickle Cell Disease (SCD). n.d. https://www.cdc.gov/ncbddd/sicklecell/index.html ). Red blood cells contain hemoglobin which is responsible for carrying oxygen to the body. The genetic abnormality in sickle cell disease leads to a change in the shape of the red blood cell which results in vaso-occlusion and impaired blood flow. Vaso-occlusion leads to tissue damage and a resulting vasculopathy. Sickle cell disease can manifest with a variety of acute and chronic complications including pain, increased risk of infection, anemia, stroke, and others.

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Sickle Cell Disease

  • Gayle M. Smink

摘要

Sickle cell disease is a rare inherited, lifelong blood disorder affecting an estimated 100,000 individuals in the United States (Centers for Disease Control and Prevention. Sickle Cell Disease (SCD). n.d. https://www.cdc.gov/ncbddd/sicklecell/index.html ). Red blood cells contain hemoglobin which is responsible for carrying oxygen to the body. The genetic abnormality in sickle cell disease leads to a change in the shape of the red blood cell which results in vaso-occlusion and impaired blood flow. Vaso-occlusion leads to tissue damage and a resulting vasculopathy. Sickle cell disease can manifest with a variety of acute and chronic complications including pain, increased risk of infection, anemia, stroke, and others.