This extract from Coleman’s novel about a family adapting to memory loss encapsulates the cultural significance of dementia’s material presence as something rooted in basic biological mechanisms occurring inside the brain. This hidden and intangible connection between the inner materiality of a diminishing or disappearing brain and people’s embodied, everyday experiences in the social world is deeply problematic. It is not only problematic for those for whom the identified cause of their problems fails to manifest itself in a way that could signify to others, through some change to their outward appearance, the reasons for their failings; it is also problematic for those who seek to identify, study and alter these biological mechanisms in a bid to treat or prevent dementia from occurring. It is the endeavours of precisely these people, namely clinicians and scientists, working in the fields of dementia research in the UK and internationally, who are the focus of this chapter. By tracking the historical trajectory of dementia through secondary accounts and situating these alongside interview accounts with leading dementia researchers working in public health, clinical science, genetics and base biology, this chapter directly attends to the ways in which this problem—the connection and translation between the brain and its biological mechanisms, on the one hand, and the mind and experiences, on the other—is presented, accounted for and made into a ‘doable problem’ (Fujimura, Constructing “do-able” problems in cancer research: Articulating alignment. Social Studies of Science, 17(2), 257–293, 1987; Hillman et al., Pathways and prospects in cancer research: Securing futures and negotiating boundaries. BioSocieties, 12, 321–342, 2017) across the multiple fields of dementia research. These scientists and practitioners are engaged, just as Coleman’s character imagines, in practices to give dementia a presence, to make visible the gradual decline to invisibility.