Although standards and guidelines have evolved according to the paradigm shift ‘from an ideal strict climate to an appropriate climate’, e.g. by discriminating between short-term and long-term fluctuations and including seasonal changes, not much has changed in practice. Implementation of non-fixed setpoints for temperature and relative humidity is often a bridge too far or even simply impossible due to limited in-house knowledge at heritage institutions and technological limitations of building’s climate control systems. In the 2010’s, research at Eindhoven University of Technology has led to the concept of dynamic climate control in which controlled variations are used to realize an optimal course of temperature and relative humidity over the year respecting collection and comfort requirements. In 2020, the spin-off DYSECO was founded to further develop this concept to a fully automated self-adaptive form of dynamic climate control to enable heritage institutions to operate their air handling systems in a sustainable way for robust preventive conservation. All air handling units at the Hermitage Amsterdam museum employ the DYSECO system since mid-2020. This paper presents the energy savings obtained from dynamic climate control (data from 2020/2021) vs static climate control (data from 2014/2015). Results for the Winter, Spring and Summer seasons show substantial savings of 55%, 57% and 43% respectively.