Effective stress management is essential for nursing school success. While some stress can be motivating, excessive stress impairs critical thinking and cognitive function. This chapter examines how different types of stress—including time pressure, performance pressure, digital pressure, and social pressure—impact learning capacity and academic performance. Understanding the neurobiological effects of stress helps students recognize why stress management is crucial for optimal learning. The chapter provides practical strategies for identifying and reducing stressors, developing effective coping mechanisms, and creating a balanced approach to nursing school demand. Case studies demonstrate how stress management influences learning outcomes and clinical performance. Interactive self-assessments and synthesis activities help students develop personalized approaches to managing stress.