Lifestyle choices impact cognitive function and learning capacity in nursing school. This chapter examines how sleep, nutrition, physical activity, and student behaviors support academic success. Understanding the neurobiological impact of these lifestyle factors helps students recognize why healthy habits are important. Building on the principles of brain-based learning and critical thinking from Part I, the chapter explores how adequate sleep, proper nutrition, physical activity, and effective student behaviors optimize academic performance. The chapter provides practical strategies for developing and maintaining healthy lifestyle habits while managing the demands of nursing school. Interactive self-assessments and synthesis activities help students develop personalized approaches to lifestyle management.