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Pericardia are currently the sole materials selected to manufacture the leaflets of the valves deployed percutaneously. Before deployment, the valves must be crimped to fit in delivery sheaths. Such a procedure might damage the leaflets that must be better analyzed and eventually prevented. The long-term durability of the pericardium depends on the material selection and processing, and the handling at implantation. They should demonstrate a long-term durability superior to the life expectancy of the patients. The issues of device anchorage and leaflet abrasion were addressed with the addition of a fabric. Foreign materials such as polymers (polyurethanes or silicones) and textile fabrics (polytetrafluoroethylene or polyethylene terephthalate) were intensively investigated to manufacture surgical valves. Intensive research programs involving polymers processed with different techniques for percutaneous devices try to challenge the pericardia. The first commercial polymeric valve has recently been granted an IDE by the FDA. Tissue engineered devices have an indisputable potential in replicating the organs. However, decades of research will likely be necessary before their clinical usage. Thousands of patients are being currently treated to restore lifelong valve function. The challenge is to achieve long-term function without damaging the most appropriate pericardium tissue.

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Pericardia Are Still the Most Select Sources to Manufacture Percutaneous Heart Valves

  • 章节

  • 发表日期：

    2025年

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  • Aisa Rassoli,
  • Xinzhe Zhao,
  • Yu Yang,
  • Daniel Chappard,
  • Ying Mao,
  • Maxime Berthelot-Richer,
  • Éric Philippe,
  • Denis Desaulniers,
  • Georgi Marinov,
  • Jifu Mao,
  • Rachid Zegdi,
  • Tomás Cianciulli,
  • Omar Prieto,
  • Randolph Guzman,
  • Jing Lin,
  • Vincent Coulombe,
  • Martin Barbier,
  • Boyin Qin,
  • Nasser Fatouraee,
  • Lu Wang,
  • Bin Li,
  • Lucie Germain,
  • Ze Zhang,
  • Robert Guidoin

摘要

Pericardia are currently the sole materials selected to manufacture the leaflets of the valves deployed percutaneously. Before deployment, the valves must be crimped to fit in delivery sheaths. Such a procedure might damage the leaflets that must be better analyzed and eventually prevented. The long-term durability of the pericardium depends on the material selection and processing, and the handling at implantation. They should demonstrate a long-term durability superior to the life expectancy of the patients. The issues of device anchorage and leaflet abrasion were addressed with the addition of a fabric. Foreign materials such as polymers (polyurethanes or silicones) and textile fabrics (polytetrafluoroethylene or polyethylene terephthalate) were intensively investigated to manufacture surgical valves. Intensive research programs involving polymers processed with different techniques for percutaneous devices try to challenge the pericardia. The first commercial polymeric valve has recently been granted an IDE by the FDA. Tissue engineered devices have an indisputable potential in replicating the organs. However, decades of research will likely be necessary before their clinical usage. Thousands of patients are being currently treated to restore lifelong valve function. The challenge is to achieve long-term function without damaging the most appropriate pericardium tissue.