Occupational stress stems from a variety of factors including workload, job insecurity, relationships with superiors or coworkers, work-family conflict, and others. Research suggests that job-related stressors are associated with burnout, poor mental health, and suicidal behavior. People in occupations where they are concerned about their safety (e.g., police officers), exposed to traumatic injuries (e.g., military), and who are at heightened risk for compassion fatigue (e.g., counselors) are more vulnerable to burnout. This chapter aims to explore the role of stress and burnout in occupational suicide across different professions.