This study aims to improve the comprehensive quality assessment method in higher vocational colleges by using virtual Human-Computer Interaction (HCI) to address the issues of low accuracy and poor reliability in traditional assessment approaches. This study first analyzed the problems existing in the comprehensive quality assessment of students in higher vocational colleges, and then expounded the application of virtual HCI in the comprehensive quality assessment. Next, the intelligent algorithm was used to reduce the dimension to determine the main indicators evaluated in this study, and then the comprehensive quality evaluation was carried out through the virtual human-computer interaction technology evaluation. This study contrasts the approaches in Embodiment View and the notion of simplexity with the virtual human-computer interaction technology evaluation to test its effectiveness in the thorough quality evaluation of higher vocational students. The findings indicate that the seventh evaluation method’s accuracy can reach 93.9%, whereas Embodiment View and the notion of simplexity’s accuracy is 85.4% and 80.4%, respectively. Additionally, the A10 index approach used in this study has an internal consistency level that can reach 94.5%, while the method in the Embodiment View was only 78.2%, and the method in the notion of simplexity was only 83.2%. The results show that this method has the highest accuracy, the highest internal consistency, and better reliability. The study highlighted the important impact of virtual HCI technology assessment on the accuracy and reliability of students’ comprehensive quality assessment.