The thermodynamicsLaws of thermodynamics of computation is re-examined from recent progress in chemical physics, particularly in relation to non-equilibrium, or so-called open-dissipative systems. The modern integration of quantum theory with thermodynamics prompts a general modification of the entropic enquiry and specifically of the computational process. In particular the Laws of Nature are generalized to incorporate the steady state situation, dS = dE = 0, where S and E are the relevant entropyEntropy and energy of the evolving system and its environment. This development, combined with the postulate of a Gödelian self-referential rule, is discussed and considered from the notion of the Church-Turing thesisChurch-Turing thesis. A surprising consequence is also that the addition is commensurate with the principles of Einstein’s law of relativity, giving rise to alternative interpretations of the so-called black hole singularityBlack hole singularity. Further results, as regards the revised thermodynamic laws, are considered and analysed in relation to microscopic self-organization and universal evolution—including ourselves.