This chapter examines the intricate anatomy of the nose and perioral region, emphasizing their interdependent roles in facial aesthetics. It highlights the importance of the nasal tip’s dome region for defining tip projection, rotation, and shape. Structural considerations of lower lateral cartilages, including dome division, are explored in relation to functional outcomes. Attention is given to the skin-soft tissue envelope and its influence on healing and final appearance. Muscular interactions—particularly involving the orbicularis oris, levator labii superioris alaeque nasi, and associated groups—are detailed for their effects on the nasolabial angle. The alveolar process and philtral contours are discussed in terms of cultural ideals and individualized patient needs. Lip movement, posture, and how rhinoplasty maneuvers can alter upper lip length and expression are underscored. Preoperative assessments using photos or videos aid in understanding dynamic nose–lip relationships. Both surgical and minimally invasive options are presented for achieving harmony in nasolabial and perioral aesthetics. Overall, the chapter underscores a holistic approach, integrating nasal, lip, and maxillary considerations to optimize functional and aesthetic results..