Filler injections for reshaping and contouring of nose and face are nowadays a common minimally invasive office-based procedure, but it could be very dangerous with catastrophic complications like necrosis and ischemia of nasal skin envelope or blindness. So, prompot diagnosis of the signs and symptoms of ischemic process is Mandatory and beginning of the treatment could prevent devastating consequences and severe complications (Danesh-Meyer et al., Arch Ophthalmol 119(5):777–8, 2001; Douglas et al., Facial Plast Surg 20(2):117–23, 2004; Duranti et al., Dermatol Surg 24(12):1317–25, 1998; Fagien, Plast Reconstr Surg 105(1):362, 2000; Friedman et al., Dermatologic Surg 28(6):491–4, 2002; Fundarò et al., Int J Mol Sci 23, 2022; King, J Clin Aesthet Dermatol 11(7):E53–7, 2018; Lowe et al, Am Acad Dermatol 45(6):930–3, 2001; Niamtu, Oral Maxillofac Surg Clin North Am 17(1):17–28, 2005).