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Hyaluronidase has been used as a local solution to increase the diffusion capacity of local anesthetics, increasing the analgesic efficacy, and the anesthetized area particularly in the first minutes following injection, resulting in diminished intra- and postoperative pain. In aesthetic medicine, the off-label use of hyaluronidase is considered the gold standard for the management of HA-filler-associated complications or overcorrection of injection site by clinicians.

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Hyaluronidase for Non-urgent Complications: When to Use It, How to Dose It, How to Inject

  • 章节

  • 发表日期：

    2025年

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  • Shohreh Ghasemi,
  • Farhad Zeynalzadeh

摘要

Hyaluronidase has been used as a local solution to increase the diffusion capacity of local anesthetics, increasing the analgesic efficacy, and the anesthetized area particularly in the first minutes following injection, resulting in diminished intra- and postoperative pain. In aesthetic medicine, the off-label use of hyaluronidase is considered the gold standard for the management of HA-filler-associated complications or overcorrection of injection site by clinicians.