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This chapter delves into the intricate dynamics of intracranial pressure (ICP), cerebral blood flow (CBF), and brain metabolism, emphasizing their critical relevance to anesthesia. ICP is influenced by various physiological factors, including body position, arterial gas levels, blood pressure, and age. Elevated ICP can lead to severe complications, such as Cushing’s phenomenon, cerebral edema, brain herniation, and compromised cerebral blood flow autoregulation. Cerebral blood flow, vital for maintaining brain function, is regulated through autoregulatory mechanisms and chemical mediators like oxygen, carbon dioxide, and pH levels. Brain metabolism, fueled predominantly by glucose, reflects the brain’s high energy demand and sensitivity to oxygen and glucose supply. This understanding underscores the importance of optimizing cerebral hemodynamics and metabolism during anesthesia, particularly in neurocritical settings, to prevent ischemic injury and maintain neuroprotection.

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Intracranial Pressure, Cerebral Blood Flow, and Brain Metabolism: Implications for Anesthesia and Critical Care

  • 章节

  • 发表日期：

    2025年

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  • Zheng Liu,
  • Siyuan Song

摘要

This chapter delves into the intricate dynamics of intracranial pressure (ICP), cerebral blood flow (CBF), and brain metabolism, emphasizing their critical relevance to anesthesia. ICP is influenced by various physiological factors, including body position, arterial gas levels, blood pressure, and age. Elevated ICP can lead to severe complications, such as Cushing’s phenomenon, cerebral edema, brain herniation, and compromised cerebral blood flow autoregulation. Cerebral blood flow, vital for maintaining brain function, is regulated through autoregulatory mechanisms and chemical mediators like oxygen, carbon dioxide, and pH levels. Brain metabolism, fueled predominantly by glucose, reflects the brain’s high energy demand and sensitivity to oxygen and glucose supply. This understanding underscores the importance of optimizing cerebral hemodynamics and metabolism during anesthesia, particularly in neurocritical settings, to prevent ischemic injury and maintain neuroprotection.