The adverse and escalating impact of global climate change always upholds the necessity of a robust strategy and framework that initiates the significance of regional collaborative approach in India as well as the other countries of South Asia. The study critically shows the significance of collaboration to project the adverse impact of climate change at national and subregional levels through a cooperative lens. In South Asia, India experiences a dynamic physiographic characteristic that is also challenging for any researcher to set a common collaborative framework that can be impactful for India and the other countries of South Asia. The study aims to explore the in-depth analysis of present situation caused by climate change and build an acceptable framework to give a basic foundation for regional cooperation that projects the climate change’s influence. The study introduces Environmental Mitigation and Adaptation Strategy (EMAS) model for supporting a mitigation and adaptation strategy with four major parameters such as Local Awareness (LA), Adaptive Technology and Innovation (ATI), Management of Greenhouse Gas Sources (GHGM), and Climate-Friendly Initiatives (CFI), which can be a vital segmentation for any initiatives. Minor parameters under major parameters are represented as LAa = 0.4, LAb = 0.3, LAc = 0.2, LAd = 0.1 in EMAS model to build the collaborative program. The values of the parameters range from 2 to 9.5, which portrays the coding system of EMAS model and the ranked parameters required to build the approach. The EMAS model (LA, ATI, GHGM, CFI) presents a comprehensive approach here, including multiple criteria by addressing climate change in India, which can strengthen regional cooperation to improve the projection and mitigation of climate change impacts. The model deploys the scenario analysis, DPSIR model analysis, and the SWOT analysis. These three models’ interaction helps to operate the total model to approach the specific case-based scenario of different climatic disturbances. India can play the biggest and most important role here to amplify this model in their grassroots level, which can be impactful in the regional collaborative approach too. Though the model limits in some factors but it can be a light for those who want to initiate the collaboration of local-level climate change mitigation strategies with the regional contexts.