Among the main characteristics of DNA, the transport of information stands out, as opposed to the role reserved for proteins, which, among other things, convert energy and transport it, in addition to the work of sensing. Most likely for this reason, DNA has a simple structure, with only four types of nucleotides, A, T, G, and C, placed in a linear fashion in the form of a double helix. There are also certain qualities that make DNA a good structural element in the construction of nanomachines. It has the properties of persistence and stability over a length of 50 nm, with enough rigidity to be a component of molecular machinery. Furthermore, a single molecule strand is very flexible, also serving as a component of machines such as hinges or nanoactuators. In this chapter I present a history of Nanotechnologies, in particular nanomachines and their interplay with DNA molecules.