There are more than 1500 different species of bats, the only mammals capable of powered flight. Globally, bats perform critical ecosystem functions, such as insect predation, pollination, and reforestation. Like other mammals, bats are susceptible to rabies virus and other lyssaviruses. Considering that most bats are small-bodied, it is understandable why some people disregard the risks of disease related to bats and rabies. Typically, most bat bites produce little trauma compared to lesions produced by bites of wild carnivores, such as foxes, raccoons, and skunks. In 60 years of studying bats, I have found them to be fascinating creatures. For bat workers, seven common sense recommendations can prevent any serious concerns associated with handling bats. First, assume that any bat may be rabid (albeit rarely); second, use appropriate gloves when handling a bat; third, receive rabies preexposure prophylaxis; fourth, know your rabies virus neutralizing antibody titer; fifth, get a booster if your titer falls below 0.5 IU/ml; sixth, perform immediate first aid after any animal bite; seventh, seek medical attention if rabies postexposure prophylaxis is indicated. Such recommendations protect both humans and bats from the negative fallout associated with this highly virulent viral disease in a One Health context.