This narrative addresses the trajectory and challenges faced by two health professionals in Brazil in the fight against rabies, focusing on our experience gained over several decades. In 1978, a tragic case in Brasília, of a child who died of rabies after the mother did not wait for the administration of the appropriate vaccines, generated great fear and mobilized the local population. In 1973, Brazil, which faced a high incidence of human rabies cases, began to create a national control program, including animal vaccination campaigns and the training of professionals. Between 1999 and 2008, a multidisciplinary team was formed to control rabies, carrying out vaccination campaigns, monitoring diagnoses and creating zoonosis control centers. During this period, cases of rabies transmitted by dogs decreased, while those transmitted by wildlife, such as bats, increased. In the early 2000s, Brazil faced outbreaks of rabies transmitted by bats in riverside communities, which highlighted the need for specific strategies for these populations and highlighted the difficulties in dealing with this zoonosis due to the cultural diversity in Amazonic Region. In addition, new challenges, such as wildlife rabies emerged, requiring actions aimed at monitoring and controlling marmosets, wild canines, and bats. In addition, Brazil made progress in the treatment of human cases of rabies, with the adaptation of the Milwaukee protocol to the Recife protocol, allowing for the successful treatment of patients. Today, rabies continues to be a public health problem in Brazil, thus exemplifying the importance of a One Health approach, which integrates efforts from multiple sectors for effective rabies prevention and control.