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Medication-related osteonecrosis of the jaw (MRONJ) is defined as necrotic bone tissue exposed into the oral cavity that does not heal in approximately 1–3 months manifested in a patient who has received antiresorptive, antiangiogenic, or RANK ligand inhibitor drugs, with no history of head and neck radiation or oral metastasis. The condition may involve both mandible and maxilla. MRONJ can affect the quality of life and may cause severe morbidity. Its management is controversial and can involve only conservative medical care or extensive surgical procedures. The use of photobiomodulation has been shown to be an important tool that presents good results when associated with other treatment modalities.

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Medication-Related Osteonecrosis of Jaws

  • 章节

  • 发表日期：

    2025年

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  • Luiz Alcino Monteiro Gueiros,
  • Letícia Lang,
  • Camila Barcellos Calderipe,
  • Caique Mariano Pedroso,
  • Thaís Cristina Esteves-Pereira,
  • Marcio Ajudarte Lopes

摘要

Medication-related osteonecrosis of the jaw (MRONJ) is defined as necrotic bone tissue exposed into the oral cavity that does not heal in approximately 1–3 months manifested in a patient who has received antiresorptive, antiangiogenic, or RANK ligand inhibitor drugs, with no history of head and neck radiation or oral metastasis. The condition may involve both mandible and maxilla. MRONJ can affect the quality of life and may cause severe morbidity. Its management is controversial and can involve only conservative medical care or extensive surgical procedures. The use of photobiomodulation has been shown to be an important tool that presents good results when associated with other treatment modalities.