Finding sustainable and renewable fuel sources is essential to combat the depletion of existing fossil fuels and the increasing levels of pollution. Biocrude obtained from organic wastes is seen as a possible solution in this situation, with hydrothermal liquefaction (HTL) being crucial in this process. Biocrude’s promise as a renewable, high-energy-density resource is important for decreasing greenhouse gas (GHG) emissions, lessening reliance on fossil fuels, and promoting a sustainable future. This chapter focuses on providing insight into biocrude, its production and upgrading processes as well as the challenges associated with them. It also throws some light on the techno-economic, sensitivity, and lifecycle analyses. Finally, the chapter concludes with a case study on the Techno-Economic Analysis (TEA) and Life Cycle Assessment (LCA) of biocrude production and upgrading from camel manure using HTL in Qatar. The outcome of the case study is very encouraging, which suggests that producing biocrude from organic wastes through HTL has great potential for commercialization, especially during periods of high oil prices. Despite this, government subsidies are vital to guarantee the long-term profitability of biocrude production.