During the Sasanian period, commercial activities with the Indian subcontinent, especially its coastal areas, developed through the Persian Gulf and the Sea of ​​Oman. By conquering the key regions, connection between the Persian Gulf and the Sea of Oman with the islands and ports of India was facilitated. The Sasanian built camps in the coastal areas of India and gradually Zoroastrian and Nestorian Christian immigrant merchants settled there. The sailors used to travel between the ports and islands of the Persian Gulf and the Sea of Oman, loading and unloading goods. The purpose of this chapter is to investigate the trade relationship between the northern and southern shores of the Persian Gulf and the Sea of Oman with the Indian subcontinent during the Sasanian period. Relying on an analytical-descriptive approach and library method while studying documentary research, the author seeks to answer this question that how the process of economic links between these two important maritime areas was and what role it played in the mutual prosperity of these areas? Consequently, it is concluded that a set of positive factors, including the policy of port city in the Persian Gulf, the formation of a powerful commercial and military fleet, the knowledge of sea routes, and terrestrial and maritime occupation of the shores of the Indian Ocean by the Sasanian, led to the expansion of mutual prosperity of these commercial centers: the Persian Gulf, the Sea of Oman, and the Indian subcontinent.