As climate change continues to pose unprecedented challenges to global agriculture, there is an urgent need to develop sustainable strategies that enhance crop productivity while mitigating the adverse effects of environmental stressors. Plant growth-promoting rhizobacteria (PGPR) has emerged as a promising solution to address these concerns. This chapter provides a comprehensive exploration of the role of PGPR in agricultural systems and its potential to bolster climate change resilience. We delve into the multifaceted interactions between PGPR and plants, elucidating the mechanisms through which these beneficial microbes enhance nutrient uptake, stress tolerance, and overall plant health. Furthermore, we discuss the application of PGPR in various agricultural practices, from conventional farming to organic and precision agriculture. Through case studies and scientific evidence, we demonstrate how PGPR can ameliorate the impact of climate change-induced abiotic stressors, such as drought, salinity, and extreme temperatures while reducing the reliance on chemical inputs. This chapter highlights the ecological and economic advantages of adopting PGPR-based strategies, emphasising their role in fostering sustainable, climate-resilient agricultural systems. By embracing PGPR, agriculture can not only adapt to changing climatic conditions but also contribute to the mitigation of climate change effects, fostering a more sustainable and resilient future for global food production.