This study explores how cybersecurity management impacts the trustworthiness of blockchain transactions. Key challenges like 51% attacks and smart contract vulnerabilities are identified through a literature review. We propose a tailored cybersecurity framework, covering preventive, detective, and responsive measures. Empirical analysis and case studies using simulated blockchain data demonstrate significant correlations between effective cybersecurity practices and transaction reliability indicators. These include faster confirmations, lower fees, and reduced security incidents. These findings emphasize proactive cybersecurity’s critical role in building trust among blockchain stakeholders. They also stress collaboration between academia, industry, and regulatory bodies to advance cybersecurity research and enhance blockchain ecosystems’ resilience.