Nerve cell healing and regrowth is a complex and lengthy process influenced by genetic factors, damage severity, and treatment methods. Nerve tissue engineering offers innovative solutions for repairing and reconstructing damaged nerve tissues by combining cells, scaffolds, and biosignals to support tissue regeneration. Tissue scaffolds mimic the structural and functional properties of damaged tissues, promoting cell growth, proliferation, and interaction. Made from biocompatible and biodegradable polymers, these scaffolds degrade over time, allowing new tissue to form. Polyvinyl alcohol (PVA) is a biopolymer for tissue scaffolds due to its biocompatibility, biodegradability, and inhibits inflammatory responses in nerve injuries. Collagen supports regeneration by creating a biocompatible environment similar to nerve tissue. Conductive tissue scaffolds are crucial for nerve repair due to nerve cell communication occurs through electrical signals. Reduced graphene oxide (rGO), an electrically conductive nanomaterial, supports nerve cell growth and regeneration. Implanted tissue scaffolds pose risks of pain and infection; inflammation can prolong nerve healing. Therefore, conductive scaffolds can be enhanced with antibiotics and analgesics loading to support nerve repair. Controlled drug release from drug-loaded scaffolds optimizes nerve healing. Microextrusion printing technology produces three-dimensional (3D) tissue scaffolds layer by layer, creating personalized scaffolds that accelerate tissue healing. This study produced a biofunctional conductive tissue scaffold using 3D microextrusion printing technology. The scaffold, made from selected biomaterials, exhibits biomimetic properties, durability, flexibility, conductivity, biocompatibility, and contains antibiotics and analgesics to facilitate cell adhesion and proliferation. The scaffold's chemical, mechanical, electrical conductivity, and biological properties were characterized, contributing significantly to nerve tissue treatment.

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Production of Biofunctional Conductive Scaffold for Neural Tissue Engineering Applications

  • Busra Oktay,
  • Ayse Betul Bingol,
  • Israa F. Abdulazez,
  • Cem Bulent Ustundag

摘要

Nerve cell healing and regrowth is a complex and lengthy process influenced by genetic factors, damage severity, and treatment methods. Nerve tissue engineering offers innovative solutions for repairing and reconstructing damaged nerve tissues by combining cells, scaffolds, and biosignals to support tissue regeneration. Tissue scaffolds mimic the structural and functional properties of damaged tissues, promoting cell growth, proliferation, and interaction. Made from biocompatible and biodegradable polymers, these scaffolds degrade over time, allowing new tissue to form. Polyvinyl alcohol (PVA) is a biopolymer for tissue scaffolds due to its biocompatibility, biodegradability, and inhibits inflammatory responses in nerve injuries. Collagen supports regeneration by creating a biocompatible environment similar to nerve tissue. Conductive tissue scaffolds are crucial for nerve repair due to nerve cell communication occurs through electrical signals. Reduced graphene oxide (rGO), an electrically conductive nanomaterial, supports nerve cell growth and regeneration. Implanted tissue scaffolds pose risks of pain and infection; inflammation can prolong nerve healing. Therefore, conductive scaffolds can be enhanced with antibiotics and analgesics loading to support nerve repair. Controlled drug release from drug-loaded scaffolds optimizes nerve healing. Microextrusion printing technology produces three-dimensional (3D) tissue scaffolds layer by layer, creating personalized scaffolds that accelerate tissue healing. This study produced a biofunctional conductive tissue scaffold using 3D microextrusion printing technology. The scaffold, made from selected biomaterials, exhibits biomimetic properties, durability, flexibility, conductivity, biocompatibility, and contains antibiotics and analgesics to facilitate cell adhesion and proliferation. The scaffold's chemical, mechanical, electrical conductivity, and biological properties were characterized, contributing significantly to nerve tissue treatment.