Gonadotropin-releasing hormone neurons trigger the reproductive axis in mammals by exocytosis of the corresponding hormone. The release of the hormone has two modes: pulsatile and surge-like. Until recently, both modes were modelled as a result of the action potential that is initiated in the proximity of the soma and propagates to the distal part of a neuron where it facilitates one or another mode of a hormone release. New experimental data shows that the pulsatile mode persists even when the electrical activity in proximity of the soma is blocked. We model the propagation of the action potential initiated near the soma on the iSite to show that the significant loss of energy during propagation prevents the sufficient excitation of the membrane on the distal segment of GnRH dendrite to trigger the pulsatile exocytosis.