In this chapter, several topics will be addressed. We first start with a short elaboration of what science is. Then, we focus on design or designing, as this is an important part of the methodology, with which new artefacts can be created. The question that then will be addressed is what design science is all about, before we elaborate design science research. The differences between the N-sciences and A-sciences, more specifically, the difference between knowledge questions and design problems, are elaborated. We also focus on two main elements of design science research: field problems and solution concepts. These solution concepts can mostly (also) serve as boundary objects. In the end, we pay attention to the intriguing question of what kind of knowledge can be ‘produced’ by using design science research. Finally, similarities and differences between action research and design science research are elaborated.