Septic shock is a critical emergency commonly leading to hospital admissions. It’s defined as a potentially fatal organ dysfunction resulting from an excessive immune response to infection, with mortality rates varying between 10% and 40%. Prompt recognition of sepsis is key to its management. Diagnostic imaging, notably contrast-enhanced full-body CT scans, is crucial in this context, selected based on clinical indicators and symptoms. The chapter discusses the CT hypoperfusion complex in septic shock, marked by specific imaging signs. It emphasizes how understanding these signs can aid in early sepsis management and potentially enhance patient outcomes.