Acute appendicitis is the leading cause of emergency abdominal surgery in Europe and the United States, predominantly affecting individuals between the ages of adolescence and 30 years. The condition typically results from appendiceal lumen obstruction, leading to inflammation and, if untreated, potential complications like necrosis and perforation. Classical symptoms include shifting abdominal pain and tenderness at McBurney’s point. However, variations in symptoms are common, especially in children, elderly patients, and pregnant women. Diagnosis relies on clinical evaluation supported by imaging modalities such as ultrasound and CT. Contrast-enhanced CT is highly accurate for detecting appendicitis and its complications, such as perforation or abscess. The Alvarado score assists in decision-making, particularly in cases with atypical presentations. Understanding the anatomical variations of the appendix and recognizing CT findings, such as appendiceal thickening and periappendiceal inflammation, are crucial for accurate diagnosis and management. Early and accurate imaging can prevent unnecessary surgeries and improve patient outcomes.