Effective fertiliser management as one of the measures for building climate resilience in agriculture is crucial while reducing the harmful environmental impact. This chapter discusses the enhanced efficiency fertilisers (EEFs) that enhance nutrient use efficiency, strengthen the climate resilience of crops, and curb the losses of reactive nitrogen. Encouraging EEF measures involve site-specific nutrient management using precise soil tests, variable rates application of remote sensing data, controlled-release coatings on fertilisers, nitrification and urease inhibitors, and biofertilisers with nitrogen fixating microbes. These plant-science-led EEFs help to develop region- and season-specific nutrient doses, preventing over-application of nutrients. This not only reduces the emission of greenhouse gases, but it also increases the yields per unit input. Assessments directed at positive economic returns from adopting EEFs in different crops and regions. Scaled digital extension services for precision agriculture are the policy priority that requires the use of EEFs, incentives for smart equipment adoption and upgrading testing infrastructure. The mainstreaming of sound fertilisation practices across the sectors must be the crux of the transition to support food security while adapting to the climatic changes.