Ether from the alkylation of alkoxides by alkyl halides. For reaction to go smoothly, the alkyl halides are preferred to be primary. Secondary halides work as well sometimes, but tertiary halides do not work at all because E2 elimination will be the predominant reaction pathway.

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Williamson Ether Synthesis

  • Jie Jack Li

摘要

Ether from the alkylation of alkoxides by alkyl halides. For reaction to go smoothly, the alkyl halides are preferred to be primary. Secondary halides work as well sometimes, but tertiary halides do not work at all because E2 elimination will be the predominant reaction pathway.