The treatment of meniscus injuries remains challenging despite common surgical interventions, such as partial meniscectomy or repair. Meniscal allograft transplantation and synthetic meniscal scaffolds have been attempted, yet with significant limitations including high failure rates and complications. Tissue engineering offers promise, necessitating scaffold designs with appropriate mechanical properties, morphology mimicking native tissue, and compatible cell integration. Novel approaches include biologics like platelet-rich plasma, biomaterial augmentation, and meniscal substitutes, such as collagen implants. Tissue engineering utilizes various cell sources and scaffold materials, showing potential in preclinical studies. Recent developments include scaffold-free constructs and anatomically inspired designs. Clinical outcomes of a novel bioabsorbable meniscal scaffold coated with polylactic acid/caprolactone show promising improvements in pain and function scores, though challenges remain in scaffold resorption and suture strength. Future research aims to optimize scaffold design, address mechanical issues, and refine rehabilitation protocols for the enhancement of clinical outcomes in meniscus regeneration.

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Advances in Meniscal Tissue Engineering

  • Tomoyuki Nakasa,
  • Kazunori Shimomura,
  • Shuhei Otsuki,
  • Nobuo Adachi

摘要

The treatment of meniscus injuries remains challenging despite common surgical interventions, such as partial meniscectomy or repair. Meniscal allograft transplantation and synthetic meniscal scaffolds have been attempted, yet with significant limitations including high failure rates and complications. Tissue engineering offers promise, necessitating scaffold designs with appropriate mechanical properties, morphology mimicking native tissue, and compatible cell integration. Novel approaches include biologics like platelet-rich plasma, biomaterial augmentation, and meniscal substitutes, such as collagen implants. Tissue engineering utilizes various cell sources and scaffold materials, showing potential in preclinical studies. Recent developments include scaffold-free constructs and anatomically inspired designs. Clinical outcomes of a novel bioabsorbable meniscal scaffold coated with polylactic acid/caprolactone show promising improvements in pain and function scores, though challenges remain in scaffold resorption and suture strength. Future research aims to optimize scaffold design, address mechanical issues, and refine rehabilitation protocols for the enhancement of clinical outcomes in meniscus regeneration.