Geotechnical engineering plays a crucial role in ensuring the stability and safety of civil engineering structures such as buildings, bridges, and dams. This chapter explores the application of MATLAB in geotechnical engineering, with a focus on soil mechanics simulations. The chapter provides a comprehensive overview of topics such as stress–strain relationships, consolidation analysis, and shear strength modeling, all essential for understanding soil behavior under various loading conditions. Advanced geotechnical methods, including seepage and permeability simulations, slope stability analysis, and foundation design, are also covered. By utilizing MATLAB’s computational power, engineers can model complex soil behaviors and perform simulations that predict soil stability and risk factors associated with different construction projects. Key techniques such as the Finite Element Method (FEM) and Limit Equilibrium Methods (LEM) are applied to assess soil responses and optimize design decisions for safe and efficient construction. Through practical examples and case studies, the chapter demonstrates the use of MATLAB in solving real-world geotechnical problems, equipping civil engineers with the tools to evaluate soil stability, predict settlement, and design safe foundations.