Over the past two decades, multiple digital health interventions have emerged to address substance use prevention and treatment among youth. Over 90% of adults with a substance use disorder report that they started using alcohol and drugs before age 18 (National Center on Addiction and Substance Abuse at Columbia University. https://eric.ed.gov/?id=ED521379). Youth substance use is associated with numerous adverse health outcomes, including increased risk of future addiction and mental health disorders, injury, overdose, and death. Few digital health interventions for substance use prevention and treatment among youth leverage user-centered design approaches or user experience evaluations. This chapter proposes a Child-Centered Design Framework (CCD) for digital health interventions that focus on substance use prevention and treatment in children and youth. The CCD Framework includes five dimensions to help guide the design and development of digital interventions: (1) Social-Ecology, (2) Child Development, (3) Theories and Frameworks, (4) Interaction Design Methods, Tools, and Techniques for Children, and (5) Evaluation. This chapter concludes with a call for future research to use the CCD Framework as a guide when planning the design, development, and evaluation process of digital health interventions for children and youth.