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There are several radioisotopes utilized for diagnostic, therapeutic, or newly emerging theranostic purposes. Among them, radionuclides such as 99Mo, 131I, 90Y, 177Lu, 161Tb, 153Sm, and 166Ho have been produced in nuclear reactors. Recently, due to the growing demand for α-emitting isotopes, their production in nuclear reactors is also of interest. Production of radionuclides in nuclear reactors depends on various factors such as available neutron flux, neutron cross-section of the given nuclear reaction, the variety and amount of side products, and the specific activity of the obtained radionuclide. In most cases, the production is not limited to the target irradiation by neutrons but also comprises multi-step target processing to obtain the radionuclide in a chemical form, allowing its direct use for radiolabeling. Herein, the practical aspects of the production of medically useful radionuclides in nuclear reactors are briefly presented.

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Nuclear Reactor-Based Production of Medical Radionuclides

  • 章节

  • 发表日期：

    2025年

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  • Izabela Cieszykowska,
  • Wioletta Wojdowska,
  • Dariusz Pawlak,
  • Renata Mikołajczak

摘要

There are several radioisotopes utilized for diagnostic, therapeutic, or newly emerging theranostic purposes. Among them, radionuclides such as 99Mo, 131I, 90Y, 177Lu, 161Tb, 153Sm, and 166Ho have been produced in nuclear reactors. Recently, due to the growing demand for α-emitting isotopes, their production in nuclear reactors is also of interest. Production of radionuclides in nuclear reactors depends on various factors such as available neutron flux, neutron cross-section of the given nuclear reaction, the variety and amount of side products, and the specific activity of the obtained radionuclide. In most cases, the production is not limited to the target irradiation by neutrons but also comprises multi-step target processing to obtain the radionuclide in a chemical form, allowing its direct use for radiolabeling. Herein, the practical aspects of the production of medically useful radionuclides in nuclear reactors are briefly presented.