Introduction: Information accessibility to Web content is becoming increasingly important for people with developmental disabilities, who often face unique challenges in acquiring information due to cognitive impairments. Despite the establishment of guidelines like the Web Content Accessibility Guidelines (WCAG) 2.1, there is limited research on effective strategies to enhance Web accessibility for this population. Methods: We conducted a comprehensive review of research published in the last decade (2014–2024) using the PubMed and Google Scholar databases. The search included terms related to developmental disabilities and information accessibility in the adult population. In total, 247 articles were identified, with six meeting the criteria for detailed review. Results: Several key themes emerged from the review. Simplified formats, using plain language and visual aids, such as bar graphs and simple icons, and a user-centered design are crucial for ensuring accessibility and comprehension in individuals with intellectual and developmental disabilities. In addition, user participation in the design process can significantly enhance the usability of digital health solutions, and assistive technologies can support information accessibility. Dis-cussion: This review suggests that while the WCAG 2.1 guidelines provide a foundation, there are gaps in addressing the specific needs of people with developmental disabilities. Thus, there is a need for customized solutions that consider the diverse range of cognitive impairments and incorporate evolving technologies. Training and support, tailored to individual needs, will be critical for improving accessibility. Future research should focus on understanding the interactions between developmental disabilities and digital content processing.