Negative Pressure Wound Therapy (NPWT), also known as vacuum-assisted closure (VAC), has revolutionized wound care by applying controlled negative pressure to wound sites using specialized vacuum systems. NPWT accelerates wound healing by reducing oedema, promoting angiogenesis and blood flow, and encouraging granulation tissue formation. It also minimizes bacterial growth, reduces infection risks, and supports wound closure by promoting wound edge contraction. NPWT is widely used across medical specialties for chronic wounds, acute injuries, surgical incisions, and complex wounds. However, careful patient assessment is essential due to specific contraindications, including untreated osteomyelitis and certain anatomical considerations. In surgical dermatology, NPWT enhances post-operative recovery by maintaining a controlled environment, improving graft adherence, and expediting wound closure. The future of NPWT holds promise with advancements in portable devices and personalized wound management strategies, offering continued improvements in patient care and outcomes.