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Salivary gland cancers (SGC) are rare and heterogenous diseases underrepresented in clinical trials. Chemotherapy and unmatched targeted therapies have shown limited long-term benefit. Molecular characterization of SGC may help to unveil actionable alterations and provide prognostic insights. Matching patients to molecular alterations could be associated with improved outcomes. Here, we summarize the current state of precision oncology in SGC, focusing on already established molecular targets and the challenges associated for the clinical implementation of personalized oncology in SGC.

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Molecular Characterization of Salivary Gland Cancer and Treatment Implications

  • 章节

  • 出版模式：

    开放获取

  • 发表日期：

    2025年

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  • Alice Rossi,
  • Alberto Hernando-Calvo

摘要

Salivary gland cancers (SGC) are rare and heterogenous diseases underrepresented in clinical trials. Chemotherapy and unmatched targeted therapies have shown limited long-term benefit. Molecular characterization of SGC may help to unveil actionable alterations and provide prognostic insights. Matching patients to molecular alterations could be associated with improved outcomes. Here, we summarize the current state of precision oncology in SGC, focusing on already established molecular targets and the challenges associated for the clinical implementation of personalized oncology in SGC.