Zenker’s diverticulum (ZD) is the most common hypopharyngeal diverticulum. Patients with ZD may require surgical treatment, which can be performed via an open surgical or endoscopic approach. Endoscopic modalities have become the first-line therapy for ZD, replacing the traditional open approach, due to the minimally invasive nature of the procedures, improved rates of morbidity, and quicker postoperative recovery. A new endoscopic technique that is being used for ZD is Zenker Per Oral Endoscopic Myotomy (ZPOEM). ZPOEM has demonstrated promising results and may have certain advantages over other endoscopic treatments. The purpose of this chapter is to review the indications, technical steps, pearls and pitfalls, and outcomes for ZPOEM.