Doing business in the context of climate change presents significant challenges and opportunities for today’s companies. While companies continue to impact the environment through their production processes, they are also increasingly vulnerable to the adverse effects of the climate crisis. The potential for businesses to play a key role in mitigating and adapting to climate change is significant, particularly through the implementation of clean technologies. These technologies not only contribute to environmental sustainability but also offer new business opportunities and the potential to tap into emerging markets. However, research shows that many business responses to climate change remain inadequate and slow, with relatively few companies fully integrating climate change considerations into their core strategies. Despite growing awareness, the pace of effective action lags the urgency of the climate crisis. Over the past decade, there has been a global call from the international community for systemic responses to climate change and resource scarcity. In response to this, the water-energy-food (WEF) nexus has emerged as a promising approach. The nexus approach seeks to understand and manage the interdependencies, synergies, and trade-offs among natural resources, offering a more holistic perspective on resource management. In this chapter, we build upon previous chapter by Benites-Lazaro and Giatti (Business case on water-energy-food nexus of biofuels: challenges in learning to change. In: Handbook of climate change mitigation and adaptation. Springer International Publishing, Cham, pp 3611–3631, 2022) by focusing on the energy transition within this nexus framework. Moreover, we emphasize that doing business in the climate crisis context requires not only a shift toward clean energy but also the adoption of inclusive practices that ensure a just transition. This means that as businesses pursue sustainability, they must also consider social equity, fair labor practices, and the inclusion of marginalized communities in the transition to a low-carbon economy.