Since the publication of the fourth assessment report of the Intergovernmental Panel on Climate Change (IPCC AR4) in 2007, more attention has been paid to the interactions between urban climate change adaptation and mitigation measures. This has improved our understanding of the co-benefits and trade-offs of these measures. However, research on the sustainability and resilience co-benefits and trade-offs of adaptation and mitigation measures in cities is still scarce. This is a gap in knowledge that will be addressed in this chapter. The chapter will cover measures related to different urban sectors such as energy, building, land use, transportation, water, waste, and green infrastructure. Regarding interactions between adaptation/mitigation measures and sustainability, I will explore possible impacts on economy, justice, ecosystem, air quality, health, energy security, and resource efficiency. In terms of resilience, I will discuss how pursuing adaptation and/or mitigation measures may contribute or detract from the ability of cities to plan and prepare for, absorb, recover from, and adapt to climate change impacts. Results show that while many measures provide co-benefits, some might lead to trade-offs. Therefore, the chapter concludes with policy recommendations for maximizing co-benefits and minimizing trade-offs.