Soot is a by-product of burning organic matter, such as coal, wood, fuel oil, waste oil, paper, plastic, and household waste. The chemical composition of soot is very variable (it depends on the type of burned material and combustion conditions). Chemical analyses of the soot extract identified about 20 PAHs (polycyclic aromatic hydrocarbons). The modern way of life, especially urbanization, favors the emergence of PAHs. Exposure to soot gives a statistically significant increase in the number of lung, esophagus, pharynx, bladder, and colon cancers. 1-Hydroxypyrene is the most representative urinary metabolite from soot.