Human Exposure to Arsenic and Inorganic Arsenic Compounds
摘要
The highest concentrations of arsenic were found in seafood, meat, cereals, vegetables, fruit, and dairy products. Inorganic arsenic is the dominant form and is found in meat, poultry, dairy products, and grains. Uses of arsenic today include pharmaceuticals, wood preservatives, agricultural chemicals, mining, metallurgical, glass, and semiconductor applications. The primary route of exposure of the general population to arsenic is through consumption of contaminated food or water. Inorganic arsenic compounds cause lung, bladder, and skin cancer. Also, a positive association was observed between exposure to arsenic and inorganic arsenic compounds and cancer of the kidney, liver, and prostate. Chronic exposure of humans to inorganic arsenic has been associated with increased risk of disorders of the peripheral vasculature, diseases of the cardiovascular and cerebrovascular systems, hypertension, diabetes, and reproductive failure. Urinary arsenic metabolites commonly used as indicators of recent exposure are total inorganic arsenic, arsenobetaine, methylarsonic acid (MAA), and dimethylarsinic acid (DMAA).