A mechanistic and empirical approach to modeling the climate change impact on global ecosystem has been carried out for the period of 1923–2023. Necessarily, Coupled Model Intercomparison Project (CMIP5) data implementation in relation to Representative Concentration Pathway (RCP2.6) species decline in each biome has been conducted in the multimode average of socioeconomic pathway (SSP3) to clarify species turnover in the biomes considering anomalies in SSP3 from the earth system models (ESMs) in accordance with European Environmental Agency (ERA5) mean annual variables. Consequently, the broad risk assessment framework has been computer by the integrated assessment models (IAMs) incorporation with the Intergovernmental Panel on Climate Change (IPCC) framework for global ecosystem loss considering the Coupled Model Intercomparison Project—Phase 6 (CMIP6) of all the earth system models (ESMs). The quantitative analysis has shown that global ecosystems are currently facing a greater level of vulnerability with respect to frequency of biome losses, and species turnover frequencies due to climate change, and this risk is projected to further escalate in the future. As a result, the global imperiled ecosystem will encounter substantial challenges in absorbing CO2 to maintain a stable global environmental equilibrium for planet earth in the near future.