Advanced building design technologies have been proposed to eliminate all pathogens inside the building before they can enter the human body. Hence, the application of sonic frequency is being incorporated into building design to release high-frequency sound from building interior wall. This sound is being donated as Hossain Ultrasonic Germicidal Frequency (HuGF) that will eliminate all pathogens, including bacteria, protozoa, prion, viroid, fungus, molds, and viruses, along with coronavirus disease 2019 (COVID-19) inside the building. Hence, the interior wall of the building will generate the ultrasound wavelength (HuGF) ranging from 10 kHz to 1 MHz which will, consequently, destroy the nucleic acids, DNA, and/or RNA bonds of all the pathogens inside the building. This renders the pathogens incapable of carrying out their essential cellular functions, causing them to die in a matter of seconds. Simply, the application of calculative sonic reaction technology in advanced building design will be a novel field of science which will destroy all pathogens inside the building naturally before they invade the human bodies.