The integrated assessment models (IAMs) have been conducted by implementing data from Department of Environmental Protection (DEP), United States Department of Energy (USDOE), Intergovernmental Panel on Climate Change (IPCC), Carbon Foundation Council (CFC), Carbon Dioxide Information and Analysis Center (CDIAC), International Energy Agency (IEA), United Nations Environmental Program (UNEP), National Environmental Association Agency (NEAA), New Energy and Industrial Technology Development Organization (NEDO), National Oceanic and Atmospheric Administration (NOAA), and National Aeronautics and Space Administration (NASA) to analyze the accurate consequences of dense population on world health and climate change perplexity due to the political barriers within nations. The results suggested that the primary cause of global health issues is the substantial accumulation of pollutants in the environment, which is a direct consequence of high population densities. As a result of the overcrowded population, there has been a significant increase in the consumption of natural resources to meet the basic needs of the populace and sustain their daily existence. As a result, the main pollution in those densely populated environments increases, resulting in a crisis that impacts global public health. Subsequently, global CO2 emissions from the crowded environment globally have also been quantified in connection of dense population distribution and the result suggested that increasing carbon dioxide levels in the atmosphere is primarily due to the dense population habitants, which is the principal driver for climate change crisis. Concretely, political barriers among nations are the major causes of the global health crisis as well as the driving force for causing climate change crisis which is indeed a great threat to the survival of both humans and the planet in the near future.