Chronic wounds pose a significant challenge to global public health, with an estimated 10.5 million people affected, particularly impacting vulnerable populations such as the elderly, diabetic patients, individuals with limited mobility, patients with vascular conditions, and those with compromised immune systems. The complexity of their management underscores the importance of adopting multidisciplinary and specialized therapeutic strategies to improve healing and quality of life. Although various treatments exist, the problem remains recurrent and necessitates urgent therapeutic innovations for long-term solutions. Current treatments lack the capacity to retain exudate, mimic the morphophysiology of the cellular matrix, maintain the process of dynamic reciprocity, and release biomolecules that could facilitate wound healing processes. The most effective treatments rely on a variety of strategies, with hydrogel-type dressings playing a key role in providing an optimal healing environment. Microbial cellulose has been explored for hydrogel dressings as a drug delivery system, offering biocompatibility, nontoxicity, and modifiability to optimize properties. This research aims to produce microbial cellulose dressings that serve as a matrix for topical drug delivery. The biomass obtained from three fermentation media was analyzed: a standard Hestrin-Schramm medium (HS), a medium supplemented with coffee mucilage (HSMC), and a medium containing only coffee mucilage (MC). The findings suggest that it is possible to obtain cellulose hydrogels from coffee mucilage, offering a significant option for improving the healing of chronic wounds. This advancement represents a milestone in sustainable chemistry and green biotechnology