This work presents a digitizer circuit based on dual slope integrator, for interfacing a four-wire type resistive sensor (RX). The proposed circuit is minimalistic, comprising only an inverting amplifier, an integrator, and a comparator. The sensor is integrated into the feedback path of the inverting amplifier, which generates the necessary negative potential for the integrator to function effectively. During the charging and discharging period, two different equations are formed in terms of sensor resistance (RX) and lead resistance (RL). Solving these equations, finally, RX is determined which is independent of RL. This is the novelty of the proposed circuit which is also simple, less bulky, and economical. The circuit is powered by a single input only, and completes the measurement in one charge–discharge cycle (maximum time ≈ 86.156 ms), highlighting its other features. Simulation and experimental results indicate an average error of ± 0.56% and ± 0.82% respectively for RX in the range of 100 Ω to 175.84 Ω.