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In this work, a graphene field effect transistor (FET) biochip system has been developed on copper plated printed circuit board (PCB) at high frequency for sensitive detection of nucleic acid. This has been realized by drop casting thermally reduced graphene oxide (rGO) using commercially available graphene oxide (GO) solution, thereby facilitating mass production. The high frequency measurement, reducing the Debye screening effect has resulted in 1 pM detection limit up to a linear range of 1 nM within a detection time of around 15 min, which is one order of magnitude lower than the existing reports. Integration of the electronic interface with on-board signal generation and measurement facility enhances the capability of the system towards point-of-care diagnosis.

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Development of High Frequency Graphene FET Sensor on PCB for Detection of Nucleic Acid in Communicable Disease Diagnostics

  • 会议论文

  • 发表日期：

    2025年

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  • P. Mukherjee,
  • S. Kundu,
  • R. Das Kundu,
  • G. Choudhury,
  • S. K. Ghosh,
  • C. RoyChaudhuri

摘要

In this work, a graphene field effect transistor (FET) biochip system has been developed on copper plated printed circuit board (PCB) at high frequency for sensitive detection of nucleic acid. This has been realized by drop casting thermally reduced graphene oxide (rGO) using commercially available graphene oxide (GO) solution, thereby facilitating mass production. The high frequency measurement, reducing the Debye screening effect has resulted in 1 pM detection limit up to a linear range of 1 nM within a detection time of around 15 min, which is one order of magnitude lower than the existing reports. Integration of the electronic interface with on-board signal generation and measurement facility enhances the capability of the system towards point-of-care diagnosis.